Ribosomal subunit exchange during protein synthesis.
نویسندگان
چکیده
منابع مشابه
Ribosomal Subunit Exchange in Dictyostelium Purpureum
The rapid and frequent exchange of the 70S ribosomes in Escherichia coli, with their 50S and 30S subunits, has been established by kinetic studies and heavy isotope techniques (1-4) . While these studies were in progress, it was reported that ribosomes of Candida krusei, a eucaryote, undergo frequent exchange of ribosomal subunits (5) . It has been suggested that ribosomes dissociate and re-for...
متن کاملChanges in ribosomal protein and ribosomal RNA synthesis during rat intestinal differentiation.
Subtraction hybridization studies, used to identify genes involved in the control of enterocyte proliferation and/or differentiation, allowed detection of a clone shown to have homologies with rat, chicken, and human acidic ribosomal phosphoprotein P1. Since increases in P1 transcript have been associated with intestinal malignancy, we explored the relationship of P1 and other ribosomal protein...
متن کاملYeast Pescadillo is required for multiple activities during 60S ribosomal subunit synthesis.
The Pescadillo protein was identified via a developmental defect and implicated in cell cycle progression. Here we report that human Pescadillo and its yeast homolog (Yph1p or Nop7p) are localized to the nucleolus. Depletion of Nop7p leads to nuclear accumulation of pre-60S particles, indicating a defect in subunit export, and it interacts genetically with a tagged form of the ribosomal protein...
متن کاملThe Essential Nucleolar Yeast Protein Nop8p Controls the Exosome Function during 60S Ribosomal Subunit Maturation
The yeast nucleolar protein Nop8p has previously been shown to interact with Nip7p and to be required for 60S ribosomal subunit formation. Although depletion of Nop8p in yeast cells leads to premature degradation of rRNAs, the biochemical mechanism responsible for this phenotype is still not known. In this work, we show that the Nop8p amino-terminal region mediates interaction with the 5.8S rRN...
متن کاملTetracycline inhibition of Mycoplasma ribosomal protein synthesis.
Polyuridylic acid directed protein synthesis by ribosomes from tetracyclinesensitive and tetracycline-resistant cells of Mycoplasma laidlawii B was found to be sensitive to tetracycline. The ribosomal preparations were somewhat more sensitive to tetracycline than mixtures of ribosomes and cell membrane fragments. No requirement for an exogenous m-RNAcould be demonstrated with the latter prepara...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1968
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.61.1.106